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advantages over currently approved CDK4/6 inhibitors\n\nArticle Content:\n\nMay 26, 2022 17:10 ET\n\n\r\n | Source:\r\n \nOnconova Therapeutics, Inc.\n\n\n\n\n\nOnconova Therapeutics, Inc.\n\r\n Newtown, Pennsylvania, UNITED STATES\nNewtown, Pennsylvania, UNITED STATES\nNEWTOWN, Pa., May 26, 2022 (GLOBE NEWSWIRE) -- Onconova Therapeutics, Inc. (NASDAQ: ONTX), a clinical-stage biopharmaceutical company focused on discovering and developing novel products for patients with cancer, today announced the publication of an abstract at the American Society of Clinical Oncology (ASCO) Annual Meeting. Featured in the abstract are preclinical data from in vitro and cell-based assays that demonstrate how narazaciclib\u2019s inhibitory profile differentiates it from the FDA-approved CDK4/6 inhibitors palbociclib, ribociclib, and abemaciclib.\nKey data and conclusions from the abstract include:\nSteven M. Fruchtman, M.D., President and Chief Executive Officer of Onconova and co-author of the abstract, commented, \u201cThough revolutionary and commercially successful, currently available CDK4/6 inhibitors are limited by tolerability and safety issues as well as the unfortunate reality of primary and acquired drug resistance. This creates a pressing unmet need for novel agents that may overcome these shortcomings and provide patients with durable clinical benefit. Narazaciclib\u2019s decreased affinity for targets associated with poor tolerability, together with its increased inhibitory activity against kinases implicated in metastasis, cancer cell survival, immune suppression, and drug resistance, suggests it may address this need. We continue to explore this hypothesis in narazaciclib\u2019s clinical program and remain on track to establish a recommended Phase 2 dose by the end of the year.\u201d\nA copy of the abstract, titled, \u201cNarazaciclib\u2019s kinase inhibitory activity is differentiated from approved CDK4/6 inhibitors in preclinical models,\u201d is available on the ASCO Annual Meeting website.\nAbout Onconova Therapeutics\nOnconova Therapeutics is a clinical-stage biopharmaceutical company focused on discovering and developing novel products for patients with cancer. The Company has proprietary targeted anti-cancer agents designed to disrupt specific cellular pathways that are important for cancer cell proliferation.\nOnconova\u2019s novel, proprietary multi-kinase inhibitor narazaciclib (formerly ON 123300) is being evaluated in two separate and complementary Phase 1 dose-escalation and expansion studies. These trials are currently underway in the United States and China.\nOnconova\u2019s product candidate rigosertib is being studied in an investigator-sponsored study program, including in a dose-escalation and expansion Phase 1/2a investigator-sponsored study with oral rigosertib in combination with nivolumab for patients with KRAS+ non-small cell lung cancer.\nFor more information, please visit www.onconova.com.\nForward-Looking Statements\nSome of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995, and involve risks and uncertainties. These statements relate to Onconova\u2019s expectations regarding the timing of Onconova\u2019s and investigator-initiated clinical development and data presentation plans, and the mechanisms and indications for Onconova\u2019s product candidates. Onconova has attempted to identify forward-looking statements by terminology including \"believes,\" \"estimates,\" \"anticipates,\" \"expects,\" \"plans,\" \"intends,\" \"may,\" \"could,\" \"might,\" \"will,\" \"should,\" \u201cpreliminary,\u201d \u201cencouraging,\u201d \"approximately\" or other words that convey uncertainty of future events or outcomes. Although Onconova believes that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including the success and timing of Onconova's clinical trials, investigator-initiated trials and regulatory agency and institutional review board approvals of protocols, Onconova\u2019s collaborations, market conditions and those discussed under the heading \"Risk Factors\" in Onconova's most recent Annual Report on Form 10-K and quarterly reports on Form 10-Q. Any forward-looking statements contained in this release speak only as of its date. Onconova undertakes no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events.\n\nSource: GlobeNewswire Inc.\n", + "timestamp_ms": 1653599400000, + "published_utc": "2022-05-26T21:10:00Z", + "article_url": "https://www.globenewswire.com/news-release/2022/05/26/2451675/0/en/Onconova-Therapeutics-Announces-Abstract-at-the-ASCO-Annual-Meeting-Highlighting-Narazaciclib-s-Differentiated-Inhibitory-and-Improved-Safety-Profile-in-Preclinical-Models.html", + "label_type": [ + "[1][c] Company-Specific News", + "[2][a] Fundamental Analysis" + ], + "label_time": [ + "[1][c] Long-Term Retrospective (> 1 year)", + "[3][a] Short-Term Outlook (Next 3\u20136 months)" + ], + "label_sentiment": [ + "[1][b] Growth-Oriented" + ] + }, + "trend": { + "input_percentage_change": -14.066184618794328, + "input_bin_label": "<-4%", + "output_percentage_change": 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