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Its platform could make AGIO much more valuable by the end of this decade.\n\nArticle Content:\n\nPixelimage/E+ via Getty Images\nPixelimage/E+ via Getty Images\nAgios Pharmaceuticals (NASDAQ:AGIO) specializes in creating therapies for diseases related to cellular metabolism. Its first approved drug was Idhifa, which was approved for treating IDH mutation driven cancers, in 2017. That was followed by approval of Tibsovo for acute myeloid leukemia in 2018. In 2021 Agios sold its cancer therapy division to Servier for about $2 billion in order to concentrate on genetically defined diseases. On February 17, 2022, Agios announced that Pyrukynd (mitapivat) had been approved by the FDA for treatment of Pyruvate Kinase deficiency.\nThat is very rapid, very successful development for a biotechnology company founded in 2008. It shows the competence of Agio\u00e2\u0080\u0099s leaders and scientists as well as the potential value of its cellular metabolism platform. If Agios can follow up with more therapies that successfully treat diseases and gain FDA and global regulatory approval, it should certainly become increasingly valuable over the next decade. However, this article will focus on Pyrukynd and Agios\u00e2\u0080\u0099s current financial strength. Despite the decline in biotechnology stock indexes during the past year, investors should consider whether the current price, $28.86 per share at the close on February 22, 2022, is a good point for entry. Partly that depends on risk appetite. Note that Agios will release Q4 2021 results on February 24, 2022, that may give us more insight into expectations for Pyrukynd revenue, and for sales and marketing expenses, in 2022.\nData by YCharts\nOn February 17, 2022 Pyrukynd (mitapivat) was approved by the FDA for treatment of hemolytic anemia caused by PK (pyruvate kinase) deficiency. It is the first therapy approved for PK deficiency, which is caused by a mutation in the PKLR gene. The mutation causes a deficiency in pyruvate kinase enzyme, which in turn causes red blood cells to break down, resulting in hemolytic anemia. This leads to a variety of symptoms, including death in fetuses in the worst cases and varying degrees of anemia and its complications in most cases. Treatment prior to Pyrukynd consisted of transfusions and bone marrow transplants. In Phase 3 trials 40% of patients receiving Pyrukynd showed a hemoglobin response, compared to 0% in the placebo group. 33% of patients in a separate trial who were being treated with transfusions showed a reduction in the need for transfusion. Pyrukynd is a small molecule that works by activating the PK pathway in cells.\nPK deficiency is rare, so the number of treatable patients is not large, estimated between 3,000 and 8,000 in the U.S. and EU combined. However, PK activation may be therapeutic in other blood diseases including sickle cell disease, thalassemia, and myelodysplastic syndrome. Agios is conducting clinical trials in the first two of those indications. If label expansion is achieved the number of patients for Pyrukynd could grow substantially.\nThese last few years have seen the introduction of several new classes of therapeutics, including bispecific antibodies, gene therapy, RNAi, and mRNA. Agios\u00e2\u0080\u0099s approach uses that most traditional of medicines, the small molecule.\nThe Agios platform is based on a deep understanding of cell metabolism. Given that understanding, if something relatively simple, like a small molecule, works, there is no need for gene therapy or large molecules like antibodies. Small molecules are still prevalent in modern medicine because they offer advantages like relatively easy penetration of cell membranes and cheap production costs.\nAgios is working on a second-generation PK activator, AG-946, which is in early clinical trials. In its preclinical toolkit are other PK candidates and candidates for PAH (phenylalanine hydroxylate) and BCAT2 (branch chain amino acid aminotransferase-2) related diseases. Those diseases include phenylketonuria and acidemia, respectively.\nAt the end of Q3 2021 Agios had a cash and equivalents balance of $1.40 billion and no debt. In Q3 the company used $254 million of its cash to repurchase shares. Operating expenses for the quarter were $91 million, including $64 million for research and $27 million for administration. I expect in Q4 sales and marketing expense ramped up to prepare to sell Pyrukynd, and that will ramp further in Q1 2022. Agios execs indicated that share repurchases are no longer a priority, but more money will go into research and development, while some cash could be used to acquire an outside drug candidate or company.\nAt the closing price on February 22, 2022, of $28.86 Agios had a market capitalization of $1.60 billion. It had a 52-week high of $62.16. I believe the fall is due to the general decline in biotech stock prices. There will not be Pyrukynd revenue until Q2 2022, and ramping will take time as patients are identified and reimbursement comes online. There already exists a testing program that could increase the number of known PK Deficiency patients as we go forward. Given all that, I see Agios Pharmaceuticals as undervalued. While it will continue to burn cash for the foreseeable future, the burn rate should decline as Pyrukynd sales ramp. If the FDA does grant label expansion after results from later stage sickle cell and thalassemia trials, that would greatly increase the value of the company. In the longer run the cell metabolism analysis and drug design platform should keep generating new drug candidates and eventually revenue. I believe Agios is less risky than most companies with only one approved drug on the market, given its cash reserves and the fact that it already successfully developed three commercial drugs based on its platform.\nThis article was written by\nAnalyst\u00e2\u0080\u0099s Disclosure: I/we have a beneficial long position in the shares of AGIO either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.\nSeeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.\n\nSource: Seeking Alpha\n", + "timestamp_ms": 1645594100000, + "published_utc": "2022-02-23T05:28:20Z", + "article_url": "https://seekingalpha.com/article/4489267-agios-pharmaceuticals-stock-fda-approval-pyrukynd-buy", + "label_type": [ + "[1][c] Company-Specific News", + "[2][c] Stock Recommendations" + ], + "label_time": [ + "[2][a] Real-Time Market Developments", + "[3][a] Short-Term Outlook (Next 3\u20136 months)" + ], + "label_sentiment": [ + "[1][a] Bullish" + ] + }, + "trend": { + "input_percentage_change": 3.834595550683851, + "input_bin_label": "+2% ~ +4%", + "output_percentage_change": 2.74611452900701, + "output_bin_label": "+2% ~ +4%", + "overall_percentage_change": 9.249146757679172, + "overall_bin_label": ">+4%" + }, + "technical": { + "in_sma_10": [ + 29.3, + 29.355, + 29.243333333333336, + 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