{ "cells": [ { "cell_type": "markdown", "metadata": {}, "source": [ "# extract patient profiles from open-TCI dataset" ] }, { "cell_type": "code", "execution_count": 19, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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@IDTIMECPAMTRATEEVIDAGEWTHTM1F2A1V2
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" ], "text/plain": [ " @ID TIME CP AMT RATE EVID AGE WT HT M1F2 A1V2\n", "0 1 0.0000 0.000 39.39788 236.34 1 59 64.0 166.37 2 1\n", "1 1 0.1667 0.000 8.82647 52.98 1 59 64.0 166.37 2 1\n", "2 1 0.3333 0.000 3.92078 23.52 1 59 64.0 166.37 2 1\n", "3 1 0.5000 0.000 15.07000 30.14 1 59 64.0 166.37 2 1\n", "4 1 1.0000 6.932 0.00000 0.00 0 59 64.0 166.37 2 1" ] }, "execution_count": 19, "metadata": {}, "output_type": "execute_result" } ], "source": [ "import pandas as pd \n", "df = pd.read_csv('data.csv')\n", "df.head()" ] }, { "cell_type": "code", "execution_count": 20, "metadata": {}, "outputs": [], "source": [ "df_grouped = df.groupby('@ID')[['AGE', 'WT', 'HT', 'M1F2']].first()\n", "df_grouped = df_grouped.reset_index()" ] }, { "cell_type": "code", "execution_count": 22, "metadata": {}, "outputs": [], "source": [ "df_grouped = df_grouped.rename(columns={'@ID': 'ID', 'M1F2':'Gender'})" ] }, { "cell_type": "code", "execution_count": 24, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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IDAGEWTHTGender
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" ] }, "metadata": {}, "output_type": "display_data" } ], "source": [ "import plotly.express as px\n", "\n", "fig = px.scatter_3d(df_grouped, x='WT', y='HT', z='AGE', color='Gender', \n", " color_discrete_map = {0:'blue',1:'red'}, hover_data=['ID'])\n", "\n", "fig.update_layout(coloraxis_showscale=False, margin=dict(l=0, r=0, b=0, t=0))\n", "fig.show()" ] }, { "cell_type": "code", "execution_count": 34, "metadata": {}, "outputs": [], "source": [ "def getProfileFromID(id):\n", " return df_grouped[df_grouped.ID==id].iloc[0, 1:].to_list()" ] }, { "cell_type": "code", "execution_count": 43, "metadata": {}, "outputs": [], "source": [ "# save df_grouped to csv\n", "df_grouped.to_csv('profile_processed.csv', index=False)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "# compare different patient profiles" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "- Inputs: patient profile, BIS trace with implusive noise, noise level\n", "- Outputs: PID parameters" ] }, { "cell_type": "code", "execution_count": 57, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "(7000,)" ] }, "execution_count": 57, "metadata": {}, "output_type": "execute_result" } ], "source": [ "np.load(\"result.npy\")['BIS'].shape" ] }, { "cell_type": "code", "execution_count": 39, "metadata": {}, "outputs": [], "source": [ "from fmpy import *\n", "from fmpy import read_model_description, extract\n", "from fmpy.fmi2 import FMU2Slave\n", "import numpy as np\n", "import shutil\n", "import pandas as pd\n", "import random\n", "import plotly.graph_objects as go" ] }, { "cell_type": "code", "execution_count": 40, "metadata": {}, "outputs": [], "source": [ "derivative_control = False\n", "input_noise = False\n", "moving_average = False\n", "output_noise = False\n", "show_original = False\n", "\n", "def simulation(id):\n", " profile = getProfileFromID(id)\n", " age = profile[0]\n", " weight = profile[1]\n", " height = profile[2]\n", " gender = profile[3]\n", " vrs = {}\n", " fmu = 'Pharmacokinetics_4_comportmental_model_PI_ref_FMU_base4_OAAS_lnx.fmu'\n", " model_description = read_model_description(fmu)\n", " for variable in model_description.modelVariables:\n", " vrs[variable.name] = variable.valueReference\n", " start_time = 0.0\n", " stop_time = 7000\n", " step_size = 1\n", " unzipdir = extract(fmu)\n", " fmu = FMU2Slave(guid=model_description.guid,\n", " unzipDirectory=unzipdir,\n", " modelIdentifier=model_description.coSimulation.modelIdentifier,\n", " instanceName='instance1')\n", "\n", " # initialize\n", " fmu.instantiate()\n", " fmu.setupExperiment(startTime=start_time)\n", " fmu.enterInitializationMode()\n", " fmu.exitInitializationMode()\n", "\n", " fmu.setReal([vrs[\"amesim_interface.Age_year\"]], [age])\n", " fmu.setReal([vrs[\"amesim_interface.BIS0\"]], [95.6])\n", " fmu.setReal([vrs[\"amesim_interface.BISmin\"]], [8.9])\n", " fmu.setReal([vrs[\"amesim_interface.Drug_concentration_mgmL\"]], [20])\n", " fmu.setReal([vrs[\"amesim_interface.EC50\"]], [2.23])\n", " fmu.setReal([vrs[\"amesim_interface.Gamma\"]], [1.58])\n", " fmu.setReal([vrs[\"amesim_interface.Gender_0male_1female\"]], [gender])\n", " fmu.setReal([vrs[\"amesim_interface.Height_cm\"]], [height])\n", " fmu.setReal([vrs[\"amesim_interface.Infusion_rate_mLh\"]], [200])\n", " fmu.setReal([vrs[\"amesim_interface.Weight_kg\"]], [weight])\n", " vr_input = vrs[\"amesim_interface.Infusion_rate_mLh\"]\n", " vr_output = vrs[\"amesim_interface.BIS_Index\"]\n", "\n", "\n", " rows = [] # list to record the results\n", " time = start_time\n", " infusion_rate = 200\n", " i = 0\n", " target = 30\n", " last_error = 0\n", " last_bis = 0\n", " bis_history = []\n", " kp = 4\n", " ki = 0.01\n", " kd = kd if derivative_control else 0\n", " # simulation loop\n", " while time < stop_time:\n", "\n", " if time >= 2.4e3 and time < 4.5e3:\n", " target = 70\n", " p = 0\n", " i = 0\n", " if time >= 4.5e3:\n", " target = 30\n", " p = 0\n", " i = 0\n", "\n", " bis = fmu.getReal([int(vr_output)])[0] if time > step_size else 95.6\n", " if input_noise:\n", " bis += add_noise(min, max, std, mean)\n", " if moving_average:\n", " bis_history.append(bis)\n", " bis = bis if time <= window_size else np.mean(bis_history[-window_size:])\n", " p = bis - target\n", " i = i + p\n", " d = p - last_error\n", " last_error = p\n", " infusion_rate = np.clip(kp*p + ki*i + kd*d, 0, 200)\n", " if output_noise:\n", " infusion_rate += gen_pulsive_noise(time, min_pul, max_pul)\n", " \n", " fmu.setReal([vr_input], [int(infusion_rate)])\n", " \n", " # perform one step\n", " fmu.doStep(currentCommunicationPoint=time, communicationStepSize=step_size)\n", "\n", " # advance the time\n", " time += step_size\n", " # get the values for 'inputs' and 'outputs[4]'\n", " inputs, outputs = fmu.getReal([int(vr_input), int(vr_output)])\n", "\n", " # append the results\n", " rows.append((time, bis, inputs))\n", "\n", " fmu.terminate()\n", " fmu.freeInstance()\n", " shutil.rmtree(unzipdir, ignore_errors=True)\n", " result = np.array(rows, dtype=np.dtype([('time', np.float64), ('BIS', np.float64), ('Infusion', np.float64)]))\n", " df = pd.DataFrame(result) \n", " df['ID'] = id\n", " return df" ] }, { "cell_type": "code", "execution_count": 42, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "[WARNING] Pharmacokinetics_4_comportmental_model_PI_ref_FMU_base4_OAAS_fmi2Instantiate: the AME environment variable is undefined. Simulation could fail if the model requires datas from the Simcenter Amesim distribution\n", "[WARNING] Pharmacokinetics_4_comportmental_model_PI_ref_FMU_base4_OAAS_fmi2Instantiate: the AME environment variable is undefined. Simulation could fail if the model requires datas from the Simcenter Amesim distribution\n" ] }, { "data": { "application/vnd.plotly.v1+json": { "config": { "plotlyServerURL": "https://plot.ly" }, "data": [ { "mode": "lines", "name": "BIS for patient 6", "type": "scatter", "x": [ 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 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"automargin": true, "gridcolor": "white", "linecolor": "white", "ticks": "", "title": { "standoff": 15 }, "zerolinecolor": "white", "zerolinewidth": 2 } } }, "title": { "text": "Infusion rate evolution" }, "width": 1200 } }, "text/html": [ "
" ] }, "metadata": {}, "output_type": "display_data" } ], "source": [ "IDs = [6, 22]\n", "\n", "df_all = pd.concat([simulation(id) for id in IDs])\n", "fig1 = go.Figure()\n", "for id in IDs:\n", " df_age = df_all[df_all['ID'] == id]\n", " fig1.add_trace(go.Scatter(x=df_age.index, y=df_age['BIS'], mode='lines', name=f'BIS for patient {id}'))\n", "\n", "fig1.update_layout(height=400, width=1200, title_text=\"BIS evolution\")\n", "fig1.show()\n", "\n", "fig2 = go.Figure()\n", "for id in IDs:\n", " df_age = df_all[df_all['ID'] == id]\n", " fig2.add_trace(go.Scatter(x=df_age.index, y=df_age['Infusion'], mode='lines', name=f'Infusion rate for patient {id}'))\n", "\n", "fig2.update_layout(height=400, width=1200, title_text=\"Infusion rate evolution\")\n", "fig2.show()" ] }, { "cell_type": "code", "execution_count": null, "metadata": {}, "outputs": [], "source": [ "\n", "def add_noise(min, max, std, mean):\n", " return np.clip(np.random.normal(mean, std), min, max)\n", "\n", "def gen_pulsive_noise(count, min_val, max_val):\n", " pulse = 0\n", " n = count // 100 # Use integer division to get the floor of count / 100\n", " start = 100 * n\n", " end = start + 50\n", " if (count > start and count < end and n % 15 == 0):\n", " pulse = random.randint(min_val, max_val)\n", " \n", " return pulse\n", "def simulation(input_noise, output_noise, min, max, std, mean, min_pul, max_pul, kd, show_original, derivative_control, moving_average, window_size):\n", " vrs = {}\n", " fmu = 'Pharmacokinetics_4_comportmental_model_PI_ref_FMU_base4_OAAS_lnx.fmu'\n", " model_description = read_model_description(fmu)\n", " for variable in model_description.modelVariables:\n", " vrs[variable.name] = variable.valueReference\n", " start_time = 0.0\n", " stop_time = 7000\n", " step_size = 1\n", " unzipdir = extract(fmu)\n", "\n", " fmu = FMU2Slave(guid=model_description.guid,\n", " unzipDirectory=unzipdir,\n", " modelIdentifier=model_description.coSimulation.modelIdentifier,\n", " instanceName='instance1')\n", "\n", " # initialize\n", " fmu.instantiate()\n", " fmu.setupExperiment(startTime=start_time)\n", " fmu.enterInitializationMode()\n", " fmu.exitInitializationMode()\n", "\n", " fmu.setReal([vrs[\"amesim_interface.Age_year\"]], [60])\n", " fmu.setReal([vrs[\"amesim_interface.BIS0\"]], [95.6])\n", " fmu.setReal([vrs[\"amesim_interface.BISmin\"]], [8.9])\n", " fmu.setReal([vrs[\"amesim_interface.Drug_concentration_mgmL\"]], [20])\n", " fmu.setReal([vrs[\"amesim_interface.EC50\"]], [2.23])\n", " fmu.setReal([vrs[\"amesim_interface.Gamma\"]], [1.58])\n", " fmu.setReal([vrs[\"amesim_interface.Gender_0male_1female\"]], [1])\n", " fmu.setReal([vrs[\"amesim_interface.Height_cm\"]], [168])\n", " fmu.setReal([vrs[\"amesim_interface.Infusion_rate_mLh\"]], [200])\n", " fmu.setReal([vrs[\"amesim_interface.Weight_kg\"]], [75])\n", " vr_input = vrs[\"amesim_interface.Infusion_rate_mLh\"]\n", " vr_output = vrs[\"amesim_interface.BIS_Index\"]\n", "\n", " \n", " rows = [] # list to record the results\n", " time = start_time\n", " infusion_rate = 200\n", " i = 0\n", " target = 30\n", " last_error = 0\n", " last_bis = 0\n", " bis_history = []\n", " kp = 4\n", " ki = 0.01\n", " kd = kd if derivative_control else 0\n", " # simulation loop\n", " while time < stop_time:\n", "\n", " if time >= 2.4e3 and time < 4.5e3:\n", " target = 70\n", " p = 0\n", " i = 0\n", " if time >= 4.5e3:\n", " target = 30\n", " p = 0\n", " i = 0\n", "\n", " bis = fmu.getReal([int(vr_output)])[0] if time > step_size else 95.6\n", " if input_noise:\n", " bis += add_noise(min, max, std, mean)\n", " if moving_average:\n", " bis_history.append(bis)\n", " bis = bis if time <= window_size else np.mean(bis_history[-window_size:])\n", " p = bis - target\n", " i = i + p\n", " d = p - last_error\n", " last_error = p\n", " infusion_rate = np.clip(kp*p + ki*i + kd*d, 0, 200)\n", " if output_noise:\n", " infusion_rate += gen_pulsive_noise(time, min_pul, max_pul)\n", " \n", " fmu.setReal([vr_input], [int(infusion_rate)])\n", " \n", " # perform one step\n", " fmu.doStep(currentCommunicationPoint=time, communicationStepSize=step_size)\n", "\n", " # advance the time\n", " time += step_size\n", " # get the values for 'inputs' and 'outputs[4]'\n", " inputs, outputs = fmu.getReal([int(vr_input), int(vr_output)])\n", "\n", " # append the results\n", " rows.append((time, bis, inputs))\n", "\n", " fmu.terminate()\n", " fmu.freeInstance()\n", " shutil.rmtree(unzipdir, ignore_errors=True)\n", " result = np.array(rows, dtype=np.dtype([('time', np.float64), ('BIS', np.float64), ('Infusion', np.float64)]))\n", " df = pd.DataFrame(result) \n", " trace1 = go.Scatter(x=df.index, y=df['BIS'], mode='lines', name='BIS')\n", " fig1 = go.Figure(data=trace1)\n", " fig1.update_layout(height=400, width=1200, title_text=\"BIS evolution\")\n", "\n", " # Add a line trace for column_2 in the second subplot\n", " trace2 = go.Scatter(x=df.index, y=df['Infusion'], mode='lines', name='Infusion rate')\n", " fig2 = go.Figure(data=trace2)\n", " fig2.update_layout(height=400, width=1200, title_text=\"Infusion rate evolution\")\n", " if show_original:\n", " if input_noise:\n", " result_baseline = np.load(\"result_gaussian.npy\")\n", " elif output_noise:\n", " result_baseline = np.load(\"result_pulsive.npy\")\n", " df_original = pd.DataFrame(result_baseline)\n", " fig1.add_trace(go.Scatter(x=df_original.index, y=df_original['BIS'], mode='lines', name='BIS original', line=dict(color=\"red\"), opacity=0.5))\n", " fig2.add_trace(go.Scatter(x=df_original.index, y=df_original['Infusion'], mode='lines', name='Infusion rate original', line=dict(color=\"red\"), opacity=0.5))\n", "\n", " return fig1, fig2 " ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "# add custom BIS target and noise" ] }, { "cell_type": "code", "execution_count": null, "metadata": {}, "outputs": [], "source": [ "from fmpy import *\n", "from fmpy import read_model_description, extract\n", "from fmpy.fmi2 import FMU2Slave\n", "import numpy as np\n", "import shutil\n", "import pandas as pd\n", "import random\n", "import plotly.graph_objects as go\n", "import json\n", "\n", "df_profile = pd.read_csv(\"profile_processed.csv\")\n", "def getProfileFromID(id):\n", " return df_profile[df_profile.ID==id].iloc[0, 1:].to_list()\n", "\n", "def simulation(id, kp, ki, kd, bis_target=40, min_noise=50, max_noise=150):\n", " profile = getProfileFromID(id)\n", " age = profile[0]\n", " weight = profile[1]\n", " height = profile[2]\n", " gender = profile[3]\n", " vrs = {}\n", " fmu = 'Pharmacokinetics_4_comportmental_model_PI_ref_FMU_base4_OAAS_lnx.fmu'\n", " model_description = read_model_description(fmu)\n", " for variable in model_description.modelVariables:\n", " vrs[variable.name] = variable.valueReference\n", " start_time = 0.0\n", " stop_time = 7000\n", " step_size = 1\n", " unzipdir = extract(fmu)\n", "\n", " fmu = FMU2Slave(guid=model_description.guid,\n", " unzipDirectory=unzipdir,\n", " modelIdentifier=model_description.coSimulation.modelIdentifier,\n", " instanceName='instance1')\n", "\n", " # initialize\n", " fmu.instantiate()\n", " fmu.setupExperiment(startTime=start_time)\n", " fmu.enterInitializationMode()\n", " fmu.exitInitializationMode()\n", "\n", " fmu.setReal([vrs[\"amesim_interface.Age_year\"]], [age])\n", " fmu.setReal([vrs[\"amesim_interface.BIS0\"]], [95.6])\n", " fmu.setReal([vrs[\"amesim_interface.BISmin\"]], [8.9])\n", " fmu.setReal([vrs[\"amesim_interface.Drug_concentration_mgmL\"]], [20])\n", " fmu.setReal([vrs[\"amesim_interface.EC50\"]], [2.23])\n", " fmu.setReal([vrs[\"amesim_interface.Gamma\"]], [1.58])\n", " fmu.setReal([vrs[\"amesim_interface.Gender_0male_1female\"]], [gender])\n", " fmu.setReal([vrs[\"amesim_interface.Height_cm\"]], [height])\n", " fmu.setReal([vrs[\"amesim_interface.Infusion_rate_mLh\"]], [200])\n", " fmu.setReal([vrs[\"amesim_interface.Weight_kg\"]], [weight])\n", " vr_input = vrs[\"amesim_interface.Infusion_rate_mLh\"]\n", " vr_output = vrs[\"amesim_interface.BIS_Index\"]\n", "\n", " \n", " rows = [] # list to record the results\n", " time = start_time\n", " infusion_rate = 200\n", " i = 0\n", " target = bis_target\n", " last_error = 0\n", " # simulation loop\n", " impulsive_noise = random.randint(min_noise, max_noise)\n", " print(\"noise level:\", impulsive_noise)\n", " while time < stop_time:\n", "\n", " if time >= 2.4e3 and time < 4.5e3:\n", " target = 70\n", " p = 0\n", " i = 0\n", " if time >= 4.5e3:\n", " target = bis_target\n", " p = 0\n", " i = 0\n", "\n", " bis = fmu.getReal([int(vr_output)])[0] if time > step_size else 95.6\n", " p = bis - target\n", " i = i + p\n", " d = p - last_error\n", " last_error = p\n", " infusion_rate = np.clip(kp*p + ki*i + kd*d, 0, 200)\n", "\n", " # add impulsive noise to infusion rate\n", " n = time // 100 \n", " start = 100 * n\n", " end = start + 50\n", " if (time > start and time < end and n % 15 == 0):\n", " infusion_rate += impulsive_noise\n", " \n", " fmu.setReal([vr_input], [int(infusion_rate)])\n", " \n", " # perform one step\n", " fmu.doStep(currentCommunicationPoint=time, communicationStepSize=step_size)\n", "\n", " # advance the time\n", " time += step_size\n", " # get the values for 'inputs' and 'outputs[4]'\n", " inputs, outputs = fmu.getReal([int(vr_input), int(vr_output)])\n", "\n", " # append the results\n", " rows.append((time, bis, inputs))\n", "\n", " fmu.terminate()\n", " fmu.freeInstance()\n", " shutil.rmtree(unzipdir, ignore_errors=True)\n", " result = np.array(rows, dtype=np.dtype([('time', np.float64), ('BIS', np.float64), ('Infusion', np.float64)]))\n", " return result, impulsive_noise\n", "\n", "def plot_result(result, show_original): \n", " df = pd.DataFrame(result)\n", " trace1 = go.Scatter(x=df.index, y=df['BIS'], mode='lines', name='BIS')\n", " fig1 = go.Figure(data=trace1)\n", " fig1.update_layout(height=400, width=1200, title_text=\"BIS evolution\")\n", "\n", " # Add a line trace for column_2 in the second subplot\n", " trace2 = go.Scatter(x=df.index, y=df['Infusion'], mode='lines', name='Infusion rate')\n", " fig2 = go.Figure(data=trace2)\n", " fig2.update_layout(height=400, width=1200, title_text=\"Infusion rate evolution\")\n", " if show_original:\n", " result_baseline = np.load(\"result_impulsive.npy\")\n", " df_original = pd.DataFrame(result_baseline)\n", " fig1.add_trace(go.Scatter(x=df_original.index, y=df_original['BIS'], mode='lines', name='BIS original', line=dict(color=\"red\"), opacity=0.5))\n", " fig2.add_trace(go.Scatter(x=df_original.index, y=df_original['Infusion'], mode='lines', name='Infusion rate original', line=dict(color=\"red\"), opacity=0.5))\n", " else: \n", " np.save(\"result_impulsive.npy\", result)\n", " return fig1, fig2 \n", "\n", "def gradio_display_profile(id):\n", " profile = getProfileFromID(id)\n", " gender = \"Male\" if profile[3] == 0 else \"Female\"\n", " data = {}\n", " data[\"age\"] = [profile[0]]\n", " data[\"weight\"] = [profile[1]]\n", " data[\"height\"] = [profile[2]]\n", " data[\"gender\"] = [gender]\n", " df = pd.DataFrame(data)\n", " return df\n", "\n", "def gradio_simulation(id, kp, ki, kd, show_original, bis_target, min_noise, max_noise):\n", " result, noise_level = simulation(id, kp, ki, kd, bis_target, min_noise, max_noise)\n", " fig1, fig2 = plot_result(result, show_original)\n", " return fig1, fig2, noise_level\n", "\n", "def gradio_save(id, kp, ki, kd, bis_target, min_noise, max_noise):\n", " result, noise_level = simulation(id, kp, ki, kd, bis_target, min_noise, max_noise)\n", " patient_profile = getProfileFromID(id)\n", "\n", "\n", " # Assuming patient_profile is a list of 4 integers, bis_trace is a list of 7000 floats, and kp, ki, kd are floats\n", " data = {\n", " 'inputs': {\n", " 'patient_profile': {\n", " 'age': patient_profile[0],\n", " 'weight': patient_profile[1],\n", " 'height': patient_profile[2],\n", " 'gender': patient_profile[3]\n", " },\n", " 'bis_trace': result['BIS'].tolist(),\n", " 'noise_level': noise_level\n", " },\n", " 'outputs': {\n", " 'kp': kp,\n", " 'ki': ki,\n", " 'kd': kd\n", " }\n", " }\n", " with open(f'saved_data/patient-{id}.json', 'w') as f:\n", " json.dump(data, f)\n", " return \"Saved\"\n" ] }, { "cell_type": "code", "execution_count": null, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "[WARNING] Pharmacokinetics_4_comportmental_model_PI_ref_FMU_base4_OAAS_fmi2Instantiate: the AME environment variable is undefined. Simulation could fail if the model requires datas from the Simcenter Amesim distribution\n", "noise level: 65\n" ] }, { "data": { "text/plain": [ "'Saved'" ] }, "metadata": {}, "output_type": "display_data" } ], "source": [ "gradio_save(0, 4, 0.01, 131, 40, 50, 150)" ] } ], "metadata": { "kernelspec": { "display_name": "base", "language": "python", "name": "python3" }, "language_info": { "codemirror_mode": { "name": "ipython", "version": 3 }, "file_extension": ".py", "mimetype": "text/x-python", "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", "version": "3.8.18" } }, "nbformat": 4, "nbformat_minor": 2 }