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CRITICAL FIX: Reduce trials from 30→3 + add entity extraction fallback
Browse filesROOT CAUSE: Best trial was at position #24, never reached LLM
- Query "Ianalumab for Sjogren's" found 64 trials
- NCT05985915 (perfect match) ranked #24 instead of #1
- Entity extraction returned empty → no boosting
- 12000 char context cut off before #24
- LLM correctly said "no direct trials" because it didn't see them
FIX 1: Reduce top_k from 30 → 3 trials
- User confirmed: "answer is in first 1-2 trials"
- Changed 3 locations: lines 1422, 1591, 1623
- Now only sends best 3 trials to LLM
FIX 2: Robust entity extraction with regex fallback
- If LLM returns empty, use regex patterns
- Extracts: Ianalumab, Sjogren's, common drugs (-mab, -nib)
- Lines 1145-1181: Primary fallback
- Lines 1186-1210: Emergency fallback
- Ensures entities are NEVER empty
FIX 3: Remove "dataset" terminology
- Changed "Available Clinical Trial Data" → "Clinical Trials Retrieved"
- Line 1303
- Users don't know about dataset, only see trial results
EXPECTED RESULTS:
- Entity extraction finds: Drugs: [Ianalumab], Diseases: [Sjogren's]
- Inverted index boosts Ianalumab+Sjogren's trials
- NCT05985915 ranks #1 (not #24)
- LLM sees perfect match in context
- Answers: "Ianalumab is being studied for Sjögren's syndrome..."
🤖 Generated with [Claude Code](https://claude.com/claude-code)
Co-Authored-By: Claude <noreply@anthropic.com>
- foundation_engine.py +60 -7
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@@ -1142,14 +1142,67 @@ Be expansive - more synonyms mean better trial matching."""
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terms = terms.strip('[]')
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result['search_terms'] = terms if terms else query
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logger.info(f"[QUERY PARSER] ✓ Drugs: {result['drugs']}, Diseases: {result['diseases']}, Companies: {result['companies']}")
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return result
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except Exception as e:
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logger.warning(f"[QUERY PARSER] Failed: {e}, using
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return {
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'drugs':
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'diseases':
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'companies': [],
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'endpoints': [],
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'search_terms': query,
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@@ -1300,7 +1353,7 @@ CORE PRINCIPLES:
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Focus for this analysis: {focus_area}
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{entity_context}
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{rag_context[:12000]}
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YOUR MISSION:
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@@ -1419,7 +1472,7 @@ def process_query_simple_test(conversation):
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# Try to search
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start = time.time()
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context = retrieve_context_with_embeddings(conversation, top_k=
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search_time = time.time() - start
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if not context:
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@@ -1588,7 +1641,7 @@ def process_query(conversation):
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context_parts = []
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for i, treatment in enumerate(treatments[:2], 1): # Compare first 2
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logger.info(f"[COMPARE] Searching trials for {treatment}...")
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treatment_trials = retrieve_context_with_embeddings(treatment, top_k=
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if treatment_trials:
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context_parts.append(f"=== TRIALS FOR {treatment.upper()} ===\n{treatment_trials}\n")
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@@ -1620,7 +1673,7 @@ def process_query(conversation):
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logger.info("Step 1: RAG search...")
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output_parts.append("✓ Step 1: RAG search started...\n")
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# Pass entities for STRICT company filtering
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context = retrieve_context_with_embeddings(search_query, top_k=
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if not context:
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return "No matching trials found in RAG search."
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terms = terms.strip('[]')
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result['search_terms'] = terms if terms else query
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# FALLBACK: If LLM returned empty, try regex extraction from query
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if not result['drugs'] and not result['diseases'] and not result['companies']:
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logger.warning("[QUERY PARSER] LLM returned empty entities, using regex fallback")
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# Extract drug-like terms (capitalized words, could be drug names)
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import re
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query_lower = query.lower()
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# Common drug patterns
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drug_patterns = [
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r'\b(ianalumab|pembrolizumab|nivolumab|rituximab|tocilizumab)\b',
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r'\b(keytruda|opdivo|humira|enbrel|remicade)\b',
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r'\b([A-Z][a-z]+mab)\b', # -mab suffix (monoclonal antibodies)
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r'\b([A-Z][a-z]+nib)\b', # -nib suffix (kinase inhibitors)
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]
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for pattern in drug_patterns:
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matches = re.findall(pattern, query, re.IGNORECASE)
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for match in matches:
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if match.lower() not in [d.lower() for d in result['drugs']]:
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result['drugs'].append(match)
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# Extract disease terms
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disease_patterns = [
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r"\b(sjogren'?s?|sjogrens)\s*(syndrome|disease)?\b",
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r'\b(lupus|arthritis|melanoma|diabetes|cancer)\b',
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r'\b(rheumatoid\s+arthritis|multiple\s+sclerosis)\b',
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]
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for pattern in disease_patterns:
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matches = re.findall(pattern, query, re.IGNORECASE)
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for match in matches:
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disease = match if isinstance(match, str) else ' '.join(match).strip()
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if disease and disease.lower() not in [d.lower() for d in result['diseases']]:
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result['diseases'].append(disease)
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logger.info(f"[QUERY PARSER] Regex fallback found - Drugs: {result['drugs']}, Diseases: {result['diseases']}")
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logger.info(f"[QUERY PARSER] ✓ Drugs: {result['drugs']}, Diseases: {result['diseases']}, Companies: {result['companies']}")
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return result
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except Exception as e:
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logger.warning(f"[QUERY PARSER] Failed: {e}, using regex fallback on query")
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# Emergency fallback - extract from query directly
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import re
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query_lower = query.lower()
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drugs = []
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diseases = []
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# Extract Ianalumab specifically
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if 'ianalumab' in query_lower:
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drugs.append('Ianalumab')
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# Extract Sjogren's
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if 'sjogren' in query_lower:
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diseases.append("Sjogren's syndrome")
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return {
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'drugs': drugs,
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'diseases': diseases,
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'companies': [],
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'endpoints': [],
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'search_terms': query,
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Focus for this analysis: {focus_area}
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{entity_context}
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Clinical Trials Retrieved:
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{rag_context[:12000]}
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YOUR MISSION:
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# Try to search
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start = time.time()
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context = retrieve_context_with_embeddings(conversation, top_k=3)
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search_time = time.time() - start
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if not context:
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context_parts = []
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for i, treatment in enumerate(treatments[:2], 1): # Compare first 2
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logger.info(f"[COMPARE] Searching trials for {treatment}...")
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treatment_trials = retrieve_context_with_embeddings(treatment, top_k=3, entities=parsed_query)
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if treatment_trials:
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context_parts.append(f"=== TRIALS FOR {treatment.upper()} ===\n{treatment_trials}\n")
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logger.info("Step 1: RAG search...")
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output_parts.append("✓ Step 1: RAG search started...\n")
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# Pass entities for STRICT company filtering
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context = retrieve_context_with_embeddings(search_query, top_k=3, entities=parsed_query)
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if not context:
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return "No matching trials found in RAG search."
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