Datasets:

AI4Protein
/

VenusMutHub

protein_id stringlengths 7 36	category stringclasses 5 values	CARP float64 -0.91 1	ESM1b float64 -0.96 1	ESM1v float64 -1 1	ESM2-650M float64 -0.94 1	ESM_IF1 float64 -1 1	ESM_IF1_multichain float64 -0.71 1 ⌀	GEMME float64 -0.96 1	MIF float64 -0.85 1	MIFST float64 -0.95 1	MSA_Transformer float64 -1 1	MULAN_small float64 -0.94 1	PoET float64 -0.94 1	VenusREM float64 -1 1	ProSSN float64 -0.96 1	ProSST-2048 float64 -1 1	Progen2-large float64 -0.9 1	ProtGPT2 float64 -0.9 1	ProteinMPNN float64 -0.94 1	ProteinMPNN_multichain float64 -0.67 0.99 ⌀	RITA-xlarge float64 -0.94 1	SaProt_650M_PDB float64 -0.99 1	Tranception_L float64 -0.9 1	Tranception_no_retrieval_L float64 -0.9 1	UniRep float64 -1 1	VESPA float64 -1 1
1BXZ_ee	selectivity	0.857143	0.857143	0.857143	0.857143	0.857143	null	0.857143	0.857143	0.857143	0.857143	0.714286	0.857143	0.857143	0.857143	0.857143	0.857143	0.571429	0.714286	null	0.857143	0.714286	0.857143	0.857143	0.571429	0.857143
1MLC_2_Kd-wtKd-mut	small_molecule_binding	0.428571	0.428571	0.428571	0.571429	0.571429	null	0.571429	0.571429	0.571429	0.714286	0.428571	0.571429	0.571429	0.571429	0.571429	0.428571	0.714286	0.285714	null	0.571429	0.571429	0.571429	0.571429	0.571429	0.571429
1Z42_ee_1	selectivity	0.828571	0.857143	0.857143	0.828571	0.857143	null	0.857143	0.857143	0.857143	0.857143	0.857143	0.8	0.857143	0.857143	0.857143	0.828571	0.742857	0.685714	null	0.857143	0.828571	0.857143	0.857143	0.542857	0.857143
1Z42_ee_2	selectivity	0.413793	0.413793	0.413793	0.413793	0.413793	null	0.413793	0.413793	0.413793	0.413793	0.413793	0.413793	0.413793	0.413793	0.413793	0.413793	0.413793	0.37931	null	0.413793	0.413793	0.413793	0.413793	0.62069	0.413793
1Z42_ee_3	selectivity	0.793103	0.793103	0.793103	0.793103	0.793103	null	0.793103	0.793103	0.793103	0.793103	0.793103	0.793103	0.793103	0.793103	0.793103	0.793103	0.655172	0.655172	null	0.793103	0.793103	0.413793	0.344828	0.586207	0.793103
2Q0Q_ee_1	selectivity	0.488889	0.422222	0.577778	0.466667	0.511111	null	0.422222	0.444444	0.444444	0.466667	0.4	0.488889	0.422222	0.422222	0.4	0.422222	0.577778	0.488889	null	0.533333	0.466667	0.511111	0.511111	0.422222	0.422222
2Q0Q_ee_2	selectivity	0.666667	0.487179	0.641026	0.589744	0.538462	null	0.487179	0.512821	0.512821	0.538462	0.461538	0.641026	0.487179	0.487179	0.512821	0.564103	0.435897	0.589744	null	0.692308	0.564103	0.615385	0.641026	0.487179	0.487179
2YLR_ee	selectivity	0.230769	0.358974	0.25641	0.230769	0.358974	null	0.358974	0.358974	0.358974	0.358974	0.307692	0.25641	0.230769	0.358974	0.230769	0.25641	0.307692	0.666667	null	0.230769	0.358974	0.384615	0.461538	0.564103	0.358974
3FCR_activity-substrate-1	activity	0.5	0.125	0.25	0.5	0.5	null	0.125	0.125	0.25	0.125	0.625	0.375	0.125	0.125	0.125	0.125	0.5	0.25	null	0.125	0.125	0.125	0.125	0.75	0.125
3FCR_activity-substrate-2	activity	0.75	0.375	0.5	0.75	0.5	null	0.375	0.375	0.5	0.375	0.625	0.625	0.375	0.375	0.375	0.375	0.5	0.75	null	0.375	0.375	0.375	0.375	0.5	0.375
4OVI_ee_2	selectivity	1	0.642857	0.928571	1	0.642857	null	0.642857	0.642857	0.642857	0.642857	0.714286	0.928571	1	0.642857	1	0.928571	0.857143	0.642857	null	1	0.642857	0.857143	0.928571	0.428571	0.642857
4OVI_ee_3	selectivity	0.6	0.6	0.6	0.6	0.6	null	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	null	0.6	0.6	0.6	0.6	0.6	0.6
4OVI_ee_4_substreate_1a	selectivity	0.5	0.666667	0.333333	0.5	0.666667	null	0.666667	0.666667	0.666667	0.666667	0.333333	0.333333	0.5	0.666667	0.5	0.5	0.5	0.5	null	0.5	0.666667	0.666667	0.666667	0.5	0.666667
5A71_ee	selectivity	0.5	0.5	0.5	0.5	0.285714	null	0.357143	0.571429	0.285714	0.428571	0.428571	0.5	0.428571	0.428571	0.5	0.428571	0.642857	0.571429	null	0.5	0.5	0.428571	0.357143	0.428571	0.428571
5A71_kcat	activity	0.5	0.333333	0.5	0.5	0.333333	null	0.333333	0.333333	0.333333	0.333333	0.166667	0.5	0.333333	0.333333	0.333333	0.5	0.333333	0.333333	null	0.5	0.333333	0.5	0.5	0.666667	0.333333
5A71_kcatkm	activity	0.666667	0.5	0.666667	0.666667	0.5	null	0.5	0.5	0.5	0.5	0.666667	0.666667	0.5	0.5	0.5	0.666667	0.5	0.5	null	0.666667	0.5	0.666667	0.666667	0.5	0.5
5Z2X_ee	selectivity	0.65	0.35	0.45	0.55	0.4	null	0.3	0.4	0.4	0.6	0.3	0.55	0.45	0.6	0.45	0.45	0.45	0.3	null	0.35	0.6	0.55	0.5	0.65	0.45
6JXG_activity	activity	0.285714	0.714286	0.428571	0.428571	0.571429	null	0.857143	0.857143	0.714286	0.571429	0.428571	0.428571	0.714286	0.857143	0.714286	0.428571	0.571429	0.285714	null	0.285714	0.571429	0.285714	0.285714	0.857143	0.857143
7LOO_activity	activity	0.588235	0.588235	0.588235	0.705882	0.588235	null	0.588235	0.588235	0.588235	0.588235	0.588235	0.588235	0.588235	0.588235	0.588235	0.588235	0.529412	0.588235	null	0.588235	0.588235	0.588235	0.588235	0.411765	0.588235
7YVR_activity	activity	0.678261	0.808696	0.704348	0.713043	0.765217	null	0.817391	0.808696	0.8	0.773913	0.713043	0.721739	0.817391	0.817391	0.817391	0.643478	0.582609	0.356522	null	0.66087	0.730435	0.73913	0.678261	0.426087	0.817391
7YVR_de	selectivity	0.847682	0.92053	0.847682	0.774834	0.675497	null	0.92053	0.834437	0.92053	0.913907	0.629139	0.821192	0.887417	0.92053	0.887417	0.84106	0.695364	0.860927	null	0.880795	0.86755	0.887417	0.900662	0.615894	0.92053
A0A059TC02_activity	activity	0.4	0.4	0.4	0.4	0.6	null	0.4	0.6	0.4	0.4	0.6	0.4	0.4	0.4	0.4	0.4	0.4	0.6	null	0.4	0.4	0.4	0.4	0.4	0.4
A0A0H2V871_DGE_activity	activity	0.692308	1	0.769231	0.615385	0.923077	null	1	1	1	0.846154	0.538462	0.769231	1	1	1	0.846154	0.846154	0.538462	null	0.923077	0.692308	1	1	0.153846	1
A0A0H2V871_Ent_activity	activity	0.692308	1	0.769231	0.615385	0.923077	null	1	1	1	0.846154	0.538462	0.769231	1	1	1	0.846154	0.846154	0.846154	null	0.923077	0.692308	1	1	0.153846	1
A0A0I9QGZ2_ee_1	selectivity	0.3	0.3	0.3	0.3	0.3	null	0.3	0.4	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.6	null	0.3	0.3	0.2	0.2	0.8	0.3
A0A0I9QGZ2_ee_2	selectivity	0.1875	0.125	0.125	0.1875	0.1875	null	0.125	0.1875	0.125	0.125	0.1875	0.1875	0.125	0.125	0.125	0.125	0.4375	0.3125	null	0.125	0.1875	0.125	0.125	0.5625	0.125
A0A0I9QGZ2_kcat	activity	0.2	0.2	0.2	0.2	0.2	null	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.4	null	0.2	0.2	0.2	0.2	0.2	0.2
A0A0I9QGZ2_kcatkm	activity	0.2	0.2	0.2	0.2	0.2	null	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.4	null	0.2	0.2	0.2	0.2	0.2	0.2
A0A0I9QGZ2_km	activity	0.2	0.2	0.2	0.2	0.2	null	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.4	null	0.2	0.2	0.2	0.2	0.2	0.2
A0A0K8P6T7_TPA_activity	activity	0.588235	0.647059	0.647059	0.588235	0.705882	null	0.647059	0.588235	0.705882	0.705882	0.470588	0.705882	0.705882	0.647059	0.647059	0.647059	0.411765	0.588235	null	0.470588	0.647059	0.470588	0.411765	0.588235	0.588235
A0A0K8P6T7_activity	activity	0.785714	0.928571	0.785714	0.857143	0.857143	null	1	0.928571	0.928571	0.928571	0.571429	0.857143	0.857143	0.928571	0.928571	0.928571	0.785714	0.928571	null	0.714286	1	0.785714	0.785714	0.285714	0.928571
A0A0K8P8E7_activity	activity	0.555556	0.777778	0.611111	0.444444	0.722222	null	0.777778	0.833333	0.777778	0.777778	0.444444	0.666667	0.777778	0.777778	0.777778	0.555556	0.555556	0.666667	null	0.5	0.833333	0.777778	0.555556	0.722222	0.777778
A0A0P0ZBS7_activity	activity	1	1	1	1	1	null	1	1	1	1	1	1	1	1	1	1	0.833333	0.833333	null	1	1	1	1	0.333333	1
A0A7I6N400_ee	selectivity	0.571429	0.571429	0.571429	0.571429	0.571429	null	0.571429	0.571429	0.571429	0.571429	0.142857	0.571429	0.571429	0.571429	0.571429	0.714286	0.428571	0.571429	null	0.428571	0.714286	0.571429	0.571429	0.714286	0.571429
A0MGZ7_substrate_VII_activity	activity	0	0.214286	0	0.142857	0	null	0.214286	0.357143	0.857143	0	0.857143	0	0.142857	0.142857	0.214286	0.214286	0.642857	0.857143	null	0.071429	0	0.428571	0.571429	0.857143	0
A0MGZ7_substrate_VI_activity	activity	0.052632	0.315789	0	0.210526	0.052632	null	0.368421	0.526316	0.894737	0.052632	0.842105	0	0.210526	0.157895	0.263158	0.315789	0.736842	0.894737	null	0.105263	0	0.526316	0.684211	0.894737	0
A2QAN3_kcat	activity	1	0.8	1	1	0.6	null	0.8	0.8	0.8	1	0.8	1	0.8	0.8	0.8	1	0.4	0.4	null	1	1	1	0.8	1	0.8
A2QAN3_kcatkm	activity	1	0.8	1	1	0.6	null	0.8	0.8	0.8	1	0.8	1	0.8	0.8	0.8	1	0.4	0.8	null	1	1	1	0.8	1	0.8
A2RJT9_DCIP_activity	activity	0.909091	0.909091	0.909091	0.909091	0.909091	null	0.909091	0.909091	0.909091	0.909091	0.909091	0.909091	0.909091	0.909091	0.909091	0.909091	0.545455	0.818182	null	0.909091	0.909091	0.909091	0.909091	0.363636	0.909091
A2RJT9_oxygen_activity	activity	0.727273	0.727273	0.727273	0.727273	0.727273	null	0.727273	0.727273	0.727273	0.727273	0.727273	0.727273	0.727273	0.727273	0.727273	0.727273	0.545455	0.363636	null	0.727273	0.727273	0.727273	0.727273	0.363636	0.727273
A4QAA6_activity	activity	0.571429	0.571429	0.428571	0.714286	0.428571	null	0.571429	0.571429	0.571429	0.428571	0.428571	0.428571	0.571429	0.571429	0.571429	0.428571	0.714286	1	null	0.571429	0.714286	0.428571	0.428571	0.571429	0.571429
A4XGA6_M5_Epimerization_activity	activity	0.857143	0.857143	0.857143	0.857143	1	null	1	0.857143	0.857143	0.857143	0.857143	0.857143	0.857143	0.857143	0.857143	0.857143	0.714286	0.714286	null	0.857143	0.857143	0.857143	0.714286	0.428571	0.857143
A4XGA6_M5_Isomerization_activity	activity	0.571429	0.857143	0.571429	0.571429	0.714286	null	0.714286	0.857143	0.571429	0.571429	0.571429	0.571429	0.714286	0.857143	0.857143	0.571429	0.428571	0.571429	null	0.571429	0.571429	0.571429	0.714286	0.428571	0.857143
ACY56506_1_km	activity	0.8	0.8	0.8	0.8	0.8	null	0.8	0.8	0.8	0.8	0.8	0.8	0.8	0.8	0.8	0.8	0.6	0.8	null	0.8	0.8	0.8	0.8	0.6	0.8
AHW42593_1_activity	activity	0.833333	0.833333	0.833333	0.666667	0.833333	null	0.833333	0.833333	0.833333	0.5	0.833333	0.833333	0.333333	0.666667	0.333333	0.5	0.666667	0.166667	null	0.833333	0.833333	0.833333	0.5	0.333333	0.833333
AHZ56660_1_kcat	activity	0.6	0.8	0.6	0.6	0.8	null	0.8	0.8	0.8	0.8	0.4	0.8	0.8	0.8	0.8	0.6	0.6	0.4	null	0.6	0.6	0.6	0.6	0.8	0.8
AHZ56660_1_km	activity	0.6	0.8	1	0.6	0.8	null	0.8	0.8	0.8	0.8	0.6	0.8	0.8	0.8	0.8	0.6	1	0.6	null	1	1	1	1	0.8	0.8
ALB07219_1_activity	activity	0.142857	0.142857	0.285714	0.142857	1	null	0.142857	0.428571	0.142857	0.142857	1	0.142857	0.142857	0.142857	0.142857	0.428571	0.428571	0.142857	null	0.571429	0.857143	0.285714	0.714286	0.285714	0.142857
BAA88830_1_activity	activity	0.631579	0.473684	0.736842	0.684211	0.631579	null	0.578947	0.315789	0.473684	0.578947	0.631579	0.736842	0.368421	0.421053	0.473684	0.473684	0.473684	0.684211	null	0.473684	0.631579	0.789474	0.736842	0.368421	0.368421
BAA_activity	activity	0.5	0.5	0.5	0.5	0.5	null	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.666667	0.666667	0.333333	null	0.5	0.5	0.5	0.5	0.666667	0.5
BindingDB_O60885_227644_Kd	small_molecule_binding	0.888889	1	1	1	0.777778	null	1	1	1	1	0.777778	1	1	1	1	1	1	0.888889	null	1	1	1	1	0.444444	1
BindingDB_P00519_13216_Kd	small_molecule_binding	0.888889	0.888889	0.777778	0.666667	0.777778	null	0.888889	0.777778	0.888889	0.888889	0.666667	0.777778	0.888889	0.888889	0.888889	0.888889	0.888889	0.777778	null	0.888889	0.777778	0.888889	0.888889	0.444444	0.888889
BindingDB_P00519_13530_Kd	small_molecule_binding	1	1	0.875	0.75	0.875	null	1	0.875	1	1	0.75	0.875	1	1	1	1	1	0.75	null	1	0.875	1	1	0.375	1
BindingDB_P00519_13534_Kd	small_molecule_binding	0.333333	0.333333	0.444444	0.555556	0.444444	null	0.333333	0.444444	0.333333	0.333333	0.555556	0.444444	0.333333	0.333333	0.333333	0.333333	0.333333	0.444444	null	0.333333	0.444444	0.444444	0.444444	0.777778	0.333333
BindingDB_P00519_4814_Kd	small_molecule_binding	0.25	0.25	0.375	0.5	0.375	null	0.25	0.375	0.25	0.25	0.5	0.375	0.25	0.25	0.25	0.25	0.25	0.25	null	0.25	0.375	0.5	0.5	0.75	0.25
BindingDB_P00519_6572_Kd	small_molecule_binding	0.555556	0.555556	0.666667	0.777778	0.666667	null	0.555556	0.666667	0.555556	0.555556	0.777778	0.666667	0.555556	0.555556	0.555556	0.555556	0.555556	0.888889	null	0.555556	0.666667	0.666667	0.666667	0.555556	0.555556
BindingDB_P00519_693815_IC50	small_molecule_binding	0.9	0.9	0.9	0.6	0.8	null	0.9	0.7	0.9	0.9	0.8	0.7	0.8	0.9	0.8	0.9	0.8	0.5	null	0.9	0.9	0.9	0.8	0.3	0.9
BindingDB_P00519_693816_IC50	small_molecule_binding	0.818182	0.818182	0.818182	0.636364	0.636364	null	0.818182	0.636364	0.818182	0.818182	0.818182	0.727273	0.818182	0.818182	0.727273	0.818182	0.818182	0.727273	null	0.818182	0.727273	0.818182	0.818182	0.272727	0.818182
BindingDB_P08483_214800_Kd	small_molecule_binding	0.933333	0.933333	0.933333	0.866667	0.933333	null	0.933333	0.933333	0.933333	0.933333	0.933333	0.933333	0.933333	0.866667	0.933333	0.933333	0.466667	0.866667	null	0.933333	0.933333	0.933333	0.933333	0.133333	0.933333
BindingDB_P08483_50004656_Ki	small_molecule_binding	0.266667	0.266667	0.266667	0.2	0.266667	null	0.266667	0.266667	0.266667	0.266667	0.266667	0.266667	0.266667	0.2	0.266667	0.266667	0.6	0.266667	null	0.266667	0.266667	0.266667	0.266667	0.8	0.266667
BindingDB_P08581_516918_IC50	small_molecule_binding	0.875	0.875	0.875	0.875	0.375	null	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.625	0.625	null	0.875	0.875	0.875	0.875	0.25	0.875
BindingDB_P08581_516919_IC50	small_molecule_binding	1	1	1	1	0.5	null	1	1	1	1	1	1	1	1	1	1	0.5	0.125	null	1	1	1	1	0.125	1
BindingDB_P08581_516963_IC50	small_molecule_binding	1	1	1	1	0.5	null	1	1	1	1	1	1	1	1	1	1	0.5	0.75	null	1	1	1	1	0.125	1
BindingDB_P08581_516969_IC50	small_molecule_binding	1	1	1	1	0.5	null	1	1	1	1	1	1	1	1	1	1	0.5	0.25	null	1	1	1	1	0.125	1
BindingDB_P08581_516999_IC50	small_molecule_binding	0.875	0.875	0.875	0.875	0.375	null	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.375	0.75	null	0.875	0.875	0.875	0.875	0.25	0.875
BindingDB_P08581_517000_IC50	small_molecule_binding	0.75	0.75	0.75	0.75	0.625	null	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.75	0.5	0.75	null	0.75	0.75	0.75	0.75	0.375	0.75
BindingDB_P08581_517003_IC50	small_molecule_binding	0.5	0.5	0.5	0.5	0.375	null	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.625	null	0.5	0.5	0.625	0.5	0.625	0.5
BindingDB_P08581_517112_IC50	small_molecule_binding	0.875	0.875	0.875	0.875	0.625	null	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.375	0.375	null	0.875	0.875	0.875	0.875	0.25	0.875
BindingDB_P08581_517113_IC50	small_molecule_binding	0.875	0.875	0.875	0.875	0.5	null	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.875	0.375	0.375	null	0.875	0.875	0.875	0.875	0.25	0.875
BindingDB_P08581_517126_IC50	small_molecule_binding	1	1	1	1	0.5	null	1	1	1	1	1	1	1	1	1	1	0.5	0.625	null	1	1	1	1	0.125	1
BindingDB_P21554_21278_Kd	small_molecule_binding	1	1	1	1	0.888889	null	1	1	1	1	1	1	1	1	0.888889	1	0.777778	0.555556	null	1	0.888889	1	1	0.444444	1
BindingDB_P21554_50072775_Kd	small_molecule_binding	0.888889	0.888889	0.888889	0.888889	0.666667	null	0.888889	0.888889	0.888889	0.888889	0.888889	0.888889	1	0.888889	1	0.888889	0.666667	1	null	0.888889	0.777778	0.888889	0.888889	0.555556	0.888889
BindingDB_P36888_621080_Kd	small_molecule_binding	0.625	0.625	0.625	0.375	0.375	null	0.625	0.625	0.625	0.625	0.625	0.5	0.625	0.625	0.625	0.625	0.625	0.625	null	0.625	0.625	0.625	0.625	0.625	0.625
BindingDB_P36888_621098_Kd	small_molecule_binding	0.25	0.25	0.25	0.5	0.5	null	0.25	0.25	0.25	0.25	0.25	0.375	0.25	0.25	0.25	0.25	0.25	0.875	null	0.25	0.25	0.25	0.25	0.75	0.25
BindingDB_P36888_621116_Kd	small_molecule_binding	0.875	0.875	0.875	0.625	0.75	null	0.875	0.875	0.875	0.875	0.875	0.75	0.875	0.875	0.875	0.875	0.875	0.5	null	0.875	0.875	0.875	0.875	0.375	0.875
BindingDB_P36888_621117_Kd	small_molecule_binding	0.625	0.625	0.625	0.625	0.625	null	0.625	0.625	0.625	0.625	0.625	0.75	0.625	0.625	0.625	0.625	0.625	0.5	null	0.625	0.625	0.625	0.625	0.375	0.625
BindingDB_P36888_621136_Kd	small_molecule_binding	0.5	0.5	0.5	0.5	0.5	null	0.5	0.5	0.5	0.5	0.5	0.625	0.5	0.5	0.5	0.5	0.5	0.5	null	0.5	0.5	0.5	0.5	0.5	0.5
BindingDB_P36888_621137_Kd	small_molecule_binding	0.5	0.5	0.5	0.5	0.5	null	0.5	0.5	0.5	0.5	0.5	0.625	0.5	0.5	0.5	0.5	0.5	0.625	null	0.5	0.5	0.5	0.5	0.5	0.5
BindingDB_P36888_621161_Kd	small_molecule_binding	0.625	0.625	0.625	0.625	0.625	null	0.625	0.625	0.625	0.625	0.625	0.75	0.625	0.625	0.625	0.625	0.625	0.625	null	0.625	0.625	0.625	0.625	0.375	0.625
BindingDB_P36888_621166_Kd	small_molecule_binding	0.75	0.75	0.75	0.75	0.75	null	0.75	0.75	0.75	0.75	0.75	0.875	0.75	0.75	0.75	0.75	0.75	0.875	null	0.75	0.75	0.75	0.75	0.25	0.75
BindingDB_P36888_621167_Kd	small_molecule_binding	0.625	0.625	0.625	0.375	0.375	null	0.625	0.625	0.625	0.625	0.625	0.5	0.625	0.625	0.625	0.625	0.625	0.625	null	0.625	0.625	0.625	0.625	0.625	0.625
BindingDB_P36888_621169_Kd	small_molecule_binding	0.75	0.75	0.75	0.75	0.75	null	0.75	0.75	0.75	0.75	0.75	0.875	0.75	0.75	0.75	0.75	0.75	0.5	null	0.75	0.75	0.75	0.75	0.25	0.75
BindingDB_P41145_21130_Ki	small_molecule_binding	1	1	1	1	0.846154	null	1	1	1	1	0.961538	1	1	1	1	1	0.653846	0.884615	null	1	0.923077	1	1	0.307692	1
BindingDB_P41145_214798_Ki	small_molecule_binding	1	1	1	1	0.807692	null	1	1	1	1	0.961538	1	1	1	1	1	0.653846	0.923077	null	1	0.923077	1	1	0.307692	1
BindingDB_P41145_214799_Ki	small_molecule_binding	0.269231	0.269231	0.269231	0.269231	0.5	null	0.269231	0.269231	0.269231	0.269231	0.307692	0.269231	0.269231	0.269231	0.269231	0.269231	0.384615	0.615385	null	0.269231	0.346154	0.269231	0.269231	0.576923	0.269231
BindingDB_P41145_50001714_Kd	small_molecule_binding	0.807692	0.807692	0.807692	0.807692	0.615385	null	0.807692	0.807692	0.807692	0.807692	0.846154	0.807692	0.807692	0.807692	0.807692	0.807692	0.538462	0.692308	null	0.807692	0.884615	0.807692	0.807692	0.346154	0.807692
BindingDB_P41145_50159165_Ki	small_molecule_binding	0.961538	0.961538	0.961538	0.961538	0.807692	null	0.961538	0.961538	0.961538	0.961538	0.923077	0.961538	0.961538	0.961538	0.961538	0.961538	0.615385	0.692308	null	0.961538	0.884615	0.961538	0.961538	0.269231	0.961538
BindingDB_Q01827_50017712_IC50	small_molecule_binding	0.75	0.75	0.75	0.75	0.75	null	0.75	0.75	0.75	0.75	0.5	0.75	0.75	0.75	0.75	0.75	0.75	0.75	null	0.625	0.625	0.625	0.625	0.5	0.75
BindingDB_Q86TI2_213827_Ki	small_molecule_binding	0.666667	0.8	0.8	0.8	0.8	null	0.8	0.8	0.8	0.8	0.666667	0.666667	0.8	0.8	0.8	0.8	0.466667	0.8	null	0.8	0.8	0.8	0.8	0.666667	0.8
BindingDB_Q873X9_10850_Kd	small_molecule_binding	0.7	0.7	0.7	0.7	0.7	null	0.7	0.7	0.7	0.7	0.6	0.7	0.7	0.7	0.7	0.7	0.7	0.4	null	0.7	0.7	0.7	0.7	0.4	0.7
BindingDB_Q873X9_10854_Kd	small_molecule_binding	1	1	1	1	1	null	1	1	1	1	0.875	1	1	1	1	1	1	0.625	null	1	1	1	1	0.125	1
C6DAH4_activity	activity	0.923077	0.923077	0.923077	0.923077	0.692308	null	0.923077	0.769231	0.923077	0.923077	0.923077	1	0.923077	0.923077	0.923077	1	0.230769	0.615385	null	0.923077	1	1	0.923077	0.692308	0.923077
CCA64021_1_activity	activity	0.857143	0.857143	0.857143	0.857143	1	null	0.857143	0.857143	0.857143	0.857143	0.428571	0.857143	0.857143	0.857143	0.857143	0.571429	0.714286	0.714286	null	0.857143	0.714286	0.857143	0.857143	0.428571	0.857143
CQR83192_1_activity	activity	0.833333	1	0.833333	0.833333	0.666667	null	1	1	0.833333	1	0.5	0.833333	1	1	1	1	1	0.333333	null	1	0.666667	1	1	0.5	1
CQR83192_1_kcat	activity	0.6	0.6	0.4	0.6	0.4	null	0.6	0.6	0.6	0.2	0.2	0.6	0.4	0.4	0.4	0.6	0.8	0.8	null	0.6	0.4	0.4	0.6	0.6	0.8
Creatinase_dTm	stability	0.448276	0.586207	0.448276	0.413793	0.517241	null	0.655172	0.62069	0.655172	0.689655	0.551724	0.551724	0.655172	0.724138	0.689655	0.448276	0.551724	0.551724	null	0.551724	0.62069	0.517241	0.413793	0.448276	0.689655
D4Z2G1_activity	activity	0.7	0.7	0.7	0.7	0.7	null	0.7	0.7	0.7	0.7	0.4	0.7	0.7	0.7	0.7	0.7	0.9	0.6	null	0.7	0.7	0.7	0.7	0.5	0.7
E8RUP5_activity	activity	0.666667	0.833333	0.666667	0.666667	0.666667	null	0.666667	0.666667	0.666667	0.5	0.833333	0.666667	0.666667	0.666667	0.666667	0.666667	0.333333	0.333333	null	0.666667	0.666667	0.666667	0.666667	0.833333	0.666667
EHK72968_1_ee	selectivity	0.375	0.375	0.25	0.25	0.5	null	0.375	0.375	0.375	0.375	0.625	0.25	0.375	0.375	0.375	0.375	0.75	0.875	null	0.375	0.5	0.625	0.5	0.25	0.375
I6XD65_NAM_activity	activity	0.285714	0	0.285714	0.142857	0	null	0.142857	0.571429	0.571429	0.142857	0.571429	0.142857	0.428571	0.142857	0.428571	0.142857	0.142857	0.142857	null	0.428571	0.142857	0.142857	0.142857	0.285714	0

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VenusMutHub Dataset

VenusMutHub is a comprehensive collection of protein mutation data designed for benchmarking and evaluating protein language models (PLMs) on various mutation effect prediction tasks. This repository contains mutation data across multiple protein properties including enzyme activity, binding affinity, stability, and selectivity.

Dataset Overview

VenusMutHub includes:

Mutation data for hundreds of proteins across diverse functional categories
Evaluation metrics for multiple protein language models
Raw mutation data with sequence information and fitness scores
DOI references for all data sources

Repository Structure

The repository is organized as follows:

`/mutant`

Contains raw mutation data organized by functional categories:

/activity: Enzyme activity data including kcat, km, and kcat/km measurements
/dti_binding: Drug-target interaction binding data
/ppi_binding: Protein-protein interaction binding data
/selectivity: Enzyme selectivity data
/stability: Protein stability measurements

Each CSV file in these directories follows the format:

mutant,mutated_sequence,fitness_score

Where:

mutant: The mutation(s) in standard notation (e.g., V109I)
mutated_sequence: The full protein sequence with the mutation(s)
fitness_score: The experimental measurement for the specific property

`/single_mutant`

Contains filtered mutation data that includes only single-point mutations, maintaining the same directory structure as /mutant. Only files with at least 5 single mutations are included.