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armanc
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pubmed-rct20k

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30
25883103
results
There was no significant difference in demographic parameters ( P > @ ) .
13
25883103
results
There were no significant differences in postoperative nausea and vomiting , otalgia , trismus , fever , or halitosis between the groups ( P > @ ) .
14
25883103
conclusions
Preemptive montelukast can be used safely to reduce the serious pain caused by tonsillectomy in children .
15
24318863
objective
Metastatic colon cancer patients are treated with the chemotherapy regimens , FOLFOX and FOLFIRI , in either order .
0
24318863
objective
So far , we can not predict the response of chemotherapeutic agent , so it is necessary to find which regimen is adequate before starting chemotherapy .
1
24318863
methods
Enrolled patients are randomized into either conventional treatment or planned treatment preceded by pretreatment genetic analysis .
2
24318863
methods
Blood samples of patients in planned treatment group ( N = @ ) were analyzed for the genetic polymorphism before selection of chemotherapeutic agents .
3
24318863
methods
Target genes were XPD-@ , GSTP-@-@ , XRCC@-@ for oxaliplatin , UGT@A@ for irinotecan .
4
24318863
methods
The response was measured by computed tomographic scan after completion of three cycles of chemotherapy .
5
24318863
results
Overall response rate was significantly higher in planned group ( @ % vs. @ % , P = @ ) .
6
24318863
results
In FOLFOX group , response rate was significantly improved in the planned patients ( @ % vs. @ % , P = @ ) .
7
24318863
results
In FOLFIRI group , the difference did n't reach statistical significance ( @ % vs. @ % , P = @ ) .
8
24318863
conclusions
We found significantly improved response rates in the chemotherapy of metastatic colon cancer by pretreatment genetic analysis , especially in FOLFOX group .
9
25872502
background
Cardiac arrest causes ischaemic brain injury .
0
25872502
background
Arterial carbon dioxide tension ( PaCO@ ) is a major determinant of cerebral blood flow .
1
25872502
background
Thus , mild hypercapnia in the @ h following cardiac arrest may increase cerebral blood flow and attenuate such injury .
2
25872502
background
We describe the Carbon Control and Cardiac Arrest ( CCC ) trial .
3
25872502
methods
The CCC trial is a pilot multicentre feasibility , safety and biological efficacy randomized controlled trial recruiting adult cardiac arrest patients admitted to the intensive care unit after return of spontaneous circulation .
4
25872502
methods
At admission , using concealed allocation , participants are randomized to @ h of either normocapnia ( PaCO@ @ to @ mmHg ) or mild hypercapnia ( PaCO@ @ to @ mmHg ) .
5
25872502
methods
Key feasibility outcomes are recruitment rate and protocol compliance rate .
6
25872502
methods
The primary biological efficacy and biological safety measures are the between-groups difference in serum neuron-specific enolase and S@b protein levels at @ h , @ h and @ h. Secondary outcome measure include adverse events , in-hospital mortality , and neurological assessment at @ months .
7
25872502
conclusions
The trial commenced in December @ and , when completed , will provide clinical evidence as to whether targeting mild hypercapnia for @ h following intensive care unit admission for cardiac arrest patients is feasible and safe and whether it results in decreased concentrations of neurological injury biomarkers compared with normocapnia .
8
25872502
conclusions
Trial results will also be used to determine whether a phase IIb study powered for survival at @ days is feasible and justified .
9
24226487
background
For decades thiopental has been considered as the hypnotic drug of choice for intracranial surgery .
0
24226487
background
However , total intravenous anesthesia performed with thiopental is associated with delayed recovery , whereas early post-operative neurological evaluation is critical .
1
24226487
background
For this reason , target controlled infusion ( TCI ) of propofol is increasingly used for maintenance of anesthesia .
2
24226487
background
However , a thiopental TCI has never been assessed for this purpose .
3
24226487
background
We tested the hypothesis that a thiopental TCI provides an acceptable way to achieve early recovery compared to a propofol TCI during supratentorial surgery .
4
24226487
methods
Eighty patients undergoing elective craniotomy for a supratentorial tumor were randomized to receive either a propofol TCI ( group P ) or a thiopental TCI ( group T ) .
5
24226487
methods
Both groups received a sufentanil TCI and the bispectral index was monitored .
6
24226487
methods
The primary end-point was time to tracheal extubation .
7
24226487
methods
Secondary end-points were per - and post-operative hemodynamics as well as respiratory and recovery parameters .
8
24226487
methods
Assessment of study end-points was performed by an intensive care specialist blinded ( like the patient ) to the received hypnotic .
9
24226487
results
Time to extubation was significantly ( P < @ ) shorter in group P ( median @ minutes ; interquartile range @-@ minutes ) than in group T ( median @ minutes ; interquartile range @-@ minutes ) .
10
24226487
results
Similarly , the recovery parameters were significantly better in group P than in group T.
11
24226487
results
There was no difference between groups in terms of patient characteristics and hemodynamic parameters .
12
24226487
conclusions
Even with TCI and bispectral index monitoring , thiopental is associated with an inappropriate delayed recovery from supratentorial surgery compared to propofol TCI .
13
25539560
objective
To investigate the effects of conservative therapy applied before arthroscopic subacromial decompression on the clinical outcome in patients with stage @ shoulder impingement syndrome .
0
25539560
methods
Sixty-eight patients having stage @ shoulder impingement syndrome and treated with arthroscopic subacromial decompression were included in the study .
1
25539560
methods
We divided these patients into @ groups , whereby @ ( @ % ) patients received conservative therapy before arthroscopic subacromial decompression and @ ( @ % ) patients did not receive conservative therapy .
2
25539560
methods
We compared both groups in terms of the the Constant , UCLA , and VAS scores for shoulder pain before and after arthroscopic subacromial decompression .
3
25539560
results
Constant , UCLA , and VAS scores were statistically significantly improved in both groups after arthroscopic subacromial decompression ( P < @ ) .
4
25539560
results
Constant , UCLA , and VAS scores before arthroscopic subacromial decompression were statistically better in Group @ than in Group @ ( P < @ ) .
5
25539560
results
No statistically significant difference was found between the groups in terms of Constant , UCLA , and VAS scores after arthroscopic subacromial decompression ( P > @ ) .
6
25539560
conclusions
Conservative therapy applied in patients with stage @ shoulder impingement syndrome before arthroscopic subacromial decompression does not have a positive contribution on the clinical outcome after arthroscopic subacromial decompression .
7
24401051
background
Obstructive sleep apnea is associated with considerable health risks .
0
24401051
background
Although continuous positive airway pressure ( CPAP ) can mitigate these risks , effectiveness can be reduced by inadequate adherence to treatment .
1
24401051
background
We evaluated the clinical safety and effectiveness of upper-airway stimulation at @ months for the treatment of moderate-to-severe obstructive sleep apnea .
2
24401051
methods
Using a multicenter , prospective , single-group , cohort design , we surgically implanted an upper-airway stimulation device in patients with obstructive sleep apnea who had difficulty either accepting or adhering to CPAP therapy .
3
24401051
methods
The primary outcome measures were the apnea-hypopnea index ( AHI ; the number of apnea or hypopnea events per hour , with a score of @ indicating moderate-to-severe apnea ) and the oxygen desaturation index ( ODI ; the number of times per hour of sleep that the blood oxygen level drops by @ percentage points from baseline ) .
4
24401051
methods
Secondary outcome measures were the Epworth Sleepiness Scale , the Functional Outcomes of Sleep Questionnaire ( FOSQ ) , and the percentage of sleep time with the oxygen saturation less than @ % .
5
24401051
methods
Consecutive participants with a response were included in a randomized , controlled therapy-withdrawal trial .
6
24401051
results
The study included @ participants ; @ % were men .
7
24401051
results
The mean age was @ years , and the mean body-mass index ( the weight in kilograms divided by the square of the height in meters ) was @ .
8
24401051
results
The median AHI score at @ months decreased @ % , from @ events per hour to @ events per hour ( P < @ ) ; the ODI score decreased @ % , from @ events per hour to @ events per hour ( P < @ ) .
9
24401051
results
Secondary outcome measures showed a reduction in the effects of sleep apnea and improved quality of life .
10
24401051
results
In the randomized phase , the mean AHI score did not differ significantly from the @-month score in the nonrandomized phase among the @ participants in the therapy-maintenance group ( @ and @ events per hour , respectively ) ; the AHI score was significantly higher ( indicating more severe apnea ) among the @ participants in the therapy-withdrawal group ( @ vs. @ events per hour , P < @ ) .
11
24401051
results
The ODI results followed a similar pattern .
12
24401051
results
The rate of procedure-related serious adverse events was less than @ % .
13
24401051
conclusions
In this uncontrolled cohort study , upper-airway stimulation led to significant improvements in objective and subjective measurements of the severity of obstructive sleep apnea .
14
24401051
conclusions
( Funded by Inspire Medical Systems ; STAR ClinicalTrials.gov number , NCT@ . )
15
26126563
objective
To identify facilitators and barriers to clinical trial implementation in Aboriginal health services .
0
26126563
methods
Indepth interview study with thematic analysis .
1
26126563
methods
Six Aboriginal community-controlled health services and one government-run service involved in the Kanyini Guidelines Adherence with the Polypill ( KGAP ) study , a pragmatic randomised controlled trial that aimed to improve adherence to indicated drug treatments for people at high risk of cardiovascular disease .
2
26126563
methods
@ health care providers and @ Aboriginal and Torres Strait Islander patients .
3
26126563
results
A fundamental enabler was that participants considered the research to be governed and endorsed by the local health service .
4
26126563
results
That the research was perceived to address a health priority for communities was also highly motivating for both providers and patients .
5
26126563
results
Enlisting the support of Aboriginal and Torres Strait Islander staff champions who were visible to the community as the main source of information about the trial was particularly important .
6
26126563
results
The major implementation barrier for staff was balancing their service delivery roles with adherence to often highly demanding trial-related procedures .
7
26126563
results
This was partially alleviated by the research team 's provision of onsite support and attempts to make trial processes more streamlined .
8
26126563
results
Although more intensive support was highly desired , there were usually insufficient resources to provide this .
9
26126563
conclusions
Despite strong community and health service support , major investments in time and resources are needed to ensure successful implementation and minimal disruption to already overstretched , routine services .
10
26126563
conclusions
Trial budgets will necessarily be inflated as a result .
11
26126563
conclusions
Funding agencies need to consider these additional resource demands when supporting trials of a similar nature .
12
24693629
objective
To compare the effect of incomplete caries removal ( ICR ) and indirect pulp capping ( IPC ) with calcium hydroxide ( CH ) or an inert material ( wax ) on color , consistency and contamination of the remaining dentin of primary molars .
0
24693629
methods
This double-blind , parallel-design , randomized controlled trial included @ children presenting one primary molar with deep caries lesion .
1
24693629
methods
Children were randomly assigned after ICR to receive IPC with CH or wax .
2
24693629
methods
All teeth were then restored with resin composite .
3
24693629
methods
Baseline dentin color and consistency were evaluated after ICR , and dentin samples were collected for contamination analyses using scanning electron microscopy .
4
24693629
methods
After @ months , restorations were removed and the three parameters were re-evaluated .
5
24693629
methods
In both groups , dentin became significantly darker after @ months .
6
24693629
results
No cases of yellow dentin were observed after @ months with CH compared to @ % of the wax cases ( P < @ ) .
7
24693629
results
A statistically significant difference over time was observed only for CH regarding consistency .
8
24693629
results
CH stimulated a dentin hardening process in a statistically higher number of cases than wax ( @ % vs. @ % ; P = @ ) .
9
24693629
results
Contamination changed significantly over time in CH and wax without significant difference between groups .
10
24693629
results
It was concluded that CH and wax arrested the carious process of the remaining carious dentin after indirect pulp capping , but CH showed superior dentin color and consistency after @ months .
11
24996519
background
In literature there is a general consensus that the use of the mirror improves proprioception .
0
24996519
background
During rehabilitation the mirror is an important instrument to improve stability .
1
24996519
background
In some sports , such as dancing , mirrors are widely used during training .
2
24996519
background
The purpose of this study is to evaluate the effectiveness of the use of a mirror on balance in young dancers .
3
24996519
background
Sixty-four young dancers ( ranging from @-@ years ) were included in this study .
4
24996519
background
Thirty-two attending lessons with a mirror ( mirror - group ) were compared to @ young dancers that attended the same lessons without a mirror ( non-mirror group ) .
5
24996519
background
Balance was evaluated by BESS ( Balance Error Scoring System ) , which consists of three stances ( double limb , single limb , and tandem ) on two surfaces ( firm and foam ) .
6
24996519
background
The errors were assessed at each stance and summed to create the two subtotal scores ( firm and foam surface ) and the final total score ( BESS ) .
7
24996519
background
The BESS was performed at recruitment ( T@ ) and after @months of dance lessons ( T@ ) .
8
24996519
results
The repeated measures ANOVA analysis showed that for the BESS total score there is a difference due to the time ( F = @ ; p < @ ) .
9
24996519
results
No other differences due to the group or to the time of measurement were found ( p > @ ) .
10
24996519
results
The analysis of the multiple regression model showed the influence of the values at T@ for every BESS items and the dominance of limb for stability on an unstable surface standing on one or two legs .
11
24996519
conclusions
These preliminary results suggest that the use of a mirror in a ballet classroom does not improve balance acquisition of the dancer .
12
24996519
conclusions
On the other hand , improvement found after @months confirms that at the age of the dancers studied motor skills and balance can easily be trained and improved .
13